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Fractyl Health procedure prevents major weight rebound a year after ending GLP-1 therapy

Source: Longevity Technology • Published: 05 Jun 2026, 11:43

Fractyl Health procedure prevents major weight rebound a year after ending GLP-1 therapy

Read about an endoscopic duodenal remodeling procedure yielding sustained weight maintenance after GLP-1 discontinuation in a one-year open-label cohort.

Key Takeaways
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  • Mean total body weight change at one year was 5.3% ± 2.1% (n=15)
  • Which the company contrasts with larger increases reported after GLP-1 withdrawal in other studies
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