Summarized by Masters of Longevity from Fight Aging!.
Reports linking age-related decline in chaperone-mediated autophagy to persistent senescent cells and a systematic review of gut microbiome shifts associated with healthy ageing.
Key Takeaways
- To what degree is the age-related failure of immune clearance of senescent cells a consequence of harmful changes in the immune system versus harmful changes in the senescent cells themselves?.
- This is an interesting and unresolved question, though there is at least some degree of evidence for contributions from both sides.
- In chaperone-mediated autophagy, an target unwanted or damaged protein is bound by a chaperone protein, and that chaperone protein facilitates the entry of the target into a lysosome for disassembly.
