A newsletter roundup covering new research on neuromuscular junction failure in sarcopenia, immune cell senescence driving bone disease, and clinical debate over p-tau217 biomarker follow-up actions.
Key Takeaways
- NMJ transmission failure and localized loss of NaV1.4 channel contribute to age-related muscle weakness
- Small molecule ClC-1 inhibition restored NMJ transmission and improved motor function in aged rats
- Immune cell senescence promotes bone resorption and impairs formation with varied roles across bone diseases