A newsletter surveying recent aging research and commentary, including SIRT3's role in disc degeneration, systemic versus cellular rejuvenation strategies, and longitudinal epigenetic clock mortality links.
Key Takeaways
- Intervertebral disc degeneration is the principal pathological basis of low back pain
- There are limited therapeutic strategies to regenerate intervertebral disc
- We found the expression of SIRT3 is significantly negatively correlated with the degree of disc degeneration in humans