Glymphatic and frailty research updates: a short roundup of a preclinical study on AQP4 modulation and a conceptual reframing of frailty as energetic congestion.
Key Takeaways
- Pharmacological activation of AQP4 with TGN-073 increased glymphatic tracer influx in mice
- Chronic TGN-073 reduced tau accumulation, neuronal loss, and gliosis while raising CSF tau levels
- AQP4-deficient PS19 mice lost TGN-073 benefits, showing effects were AQP4-dependent