Intriguing preclinical gene therapy research examining a calorie-restriction-like intervention in aged mice and its implications for aging biology.
Key Takeaways
- Muscle-directed AAV FGF21 gene therapy extended healthspan and lifespan in aged mice
- Treatment normalized body weight and adiposity and improved insulin sensitivity and glucose homeostasis
- Treated mice showed improved liver, kidney, heart, muscle, and cognitive function with reduced inflammation