A review synthesizing current knowledge on intestinal fatty acid-binding protein 2 and its roles as a biomarker and potential therapeutic target in inflammatory bowel disease.
Key Takeaways
- FABP2 is an intestine-specific lipid chaperone that sensitively indicates intestinal mucosal injury in IBD patients
- FABP2 may influence IBD pathogenesis by modulating PPARγ signaling, intestinal barrier function, and lipid metabolism
- Clinical translation of FABP2 faces challenges, requiring mechanistic studies and safe therapeutic development