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Enzymatic and chemical glycosylation of sugarcane-derived sucrose yields glycosides with moderate anti-inflammatory activity in vitro

Source: Nature - Biotechnology • Published: 09 Jul 2026, 00:00

Enzymatic and chemical glycosylation of sugarcane-derived sucrose yields glycosides with moderate anti-inflammatory activity in vitro

Enzymatic and chemical glycosylation methods to produce sugarcane-derived sucrose glycosides and evaluate their nutraceutical potential in vitro.

Key Takeaways
  • Glycosylation produced high yields between 84.9% and 86.4%
  • Compounds reduced LPS‑stimulated TNF‑α by ~35% and IL‑6 by ~33%
  • Products showed >90% simulated gastrointestinal stability and no cytotoxicity up to 200 µM
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