Circular RNA engineering research exploring scalable manufacturing, translation strategies, and preclinical therapeutic applications. Invites readers interested in RNA therapeutics and delivery innovation.
Key Takeaways
- BBV cap-independent translation enhancer drove rolling-circle translation of nucleoside-modified circRNA
- Developed PICC and RzL methods to generate scarless, RCT-enabled circRNA in vitro
- Modified circRNA encoded GLP-1 and MOG peptides with therapeutic effects in mouse models