Examine how targeting growth factor receptor signaling and protein complex formation is explored as a therapeutic strategy against renal fibrosis in preclinical research.
Key Takeaways
- Purified mimotope-induced antibodies upregulated RPL6, PCBP2, and MHC‑IB in tubular cells
- EM‑pAb promoted EGFR/RPL6/PCBP2 ternary complex formation and restored PCBP2–MHC‑IB binding
- RPL6 levels correlated significantly with kidney function in chronic kidney disease patients