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Effects of Breaking Up Prolonged Sitting on Vascular Endothelial Function in Adults: A Systematic Review

Source: Frontiers - Health • Published: 30 Jun 2026, 00:00

Effects of Breaking Up Prolonged Sitting on Vascular Endothelial Function in Adults: A Systematic Review

Assessment of evidence on how breaking up prolonged sitting influences vascular endothelial function across arterial sites and measurement methods.

Key Takeaways
  • Systematic review included 24 studies assessing interrupted sitting interventions
  • Two to three minute lower-limb breaks every twenty to thirty minutes improved blood flow
  • Flow-mediated dilation responses were heterogeneous and depended on artery measurement site
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