Examination of early blood proteomic and metabolomic changes that predict which people with diabetes progress to diabetic retinopathy within a one to two year window.
Key Takeaways
- 57 proteins were differentially expressed and enriched in metabolism and detoxification pathways
- 168 metabolites differed, implicating taurine, neuroactive ligand-receptor, and tyrosine metabolism
- Eight proteins validated by ELISA showed ROC AUCs between 0.853 and 0.945