Assess concentration-dependent nanoparticle impacts on pre-osteoblast behavior and experimental approaches for optimizing hard-tissue regenerative materials, exploring mechanisms.
Key Takeaways
- 0.01 mg/mL nanoparticle extract significantly increased MC3T3-E1 proliferation and viability
- 0.01 mg/mL condition upregulated Runx2, Ocn, and Bsp and increased ALP activity
- 10 mg/mL extract induced marked cytotoxicity in pre-osteoblast cultures