Report on a mouse study testing a BCL-2/BCL-xL–targeting senolytic for age-related intervertebral disc degeneration and observed sex-specific responses.
Key Takeaways
- But the outcomes here are somewhat less than hoped
- Systemic treatment with 753b was tested for reduction of age-related intervertebral disc degeneration (IDD)
- These results demonstrate that 753b treatment of aging mice reduced IDD in males but not females