Summarized by Masters of Longevity from Science Daily - Health & Medicine.
CRISPR-based transplant research that explores protecting healthy donor blood cells so doctors can safely deliver targeted leukemia therapies. Read to learn what kind of clinical trial and approach the article describes.

Key Takeaways
- Researchers transplanted CD33-deleted allogeneic hematopoietic stem cells into 30 patients, and the edited cells successfully engrafted.
- The CD33 deletion appeared to protect donor-derived blood cells from subsequent CD33-targeted therapy in treated patients.
- The trial reported remission in at least one TP53-mutant acute myeloid leukemia patient following the edited graft and donor-derived anti-CD33 CAR-T therapy.



