Assess recent strategies and logistical hurdles for genetically modifying donor organs during machine perfusion and translating edits to whole organs.
Key Takeaways
- Proof-of-concept gene silencing has been demonstrated in human kidney biopsy samples
- DNA-guided CRISPR–Cas systems have been shown to enable cellular RNA targeting
- CasNx secured an option to license University of Florida DNA-guided CRISPR technology