A feature examining how comparative biology and centenarian genetics are guiding efforts to boost DNA-repair systems to slow aging.
Key Takeaways
- Studies of long-lived species linked more accurate double-strand break repair to extended lifespan
- Bowhead whale cells show highly accurate double-strand break repair that limits mutational damage
- Variants in the sirtuin SIRT6 correlate with enhanced repair and appear in some long-lived lineages