Longevity News

Computationally guided design of bioactive nanostructures for targeted clearance of amyloid-β aggregates in Alzheimer’s disease

Source: Nature - Biotechnology • Published: 21 Jul 2026, 00:00

Computationally guided design of bioactive nanostructures for targeted clearance of amyloid-β aggregates in Alzheimer’s disease

Covers a computationally designed protein–gold nanocage that targets and disassembles aggregated amyloid-β, with in vivo testing in an Alzheimer's mouse model.

Key Takeaways
  • Here we report a computationally guided protein–gold hybrid nanostructure
  • Raw X-ray diffraction data for the crystal structures are available at Zenodo via https
  • Single-cell RNA sequencing data generated in this study have been deposited in the Gene Expression Omnibus (GEO)
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