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Comparative attenuation of TiO₂ nanoparticle dose-dependent toxicities in lung, spleen, and blood by nanoencapsulated wheat germ oil in male rats

Source: Nature - Biotechnology • Published: 08 Jul 2026, 00:00

Comparative attenuation of TiO₂ nanoparticle dose-dependent toxicities in lung, spleen, and blood by nanoencapsulated wheat germ oil in male rats

Assessment of nanoparticle-induced lung, spleen, and blood damage in male rats and evaluation of an encapsulated antioxidant therapy.

Key Takeaways
  • TiO2 nanoparticles accumulated mainly in lungs and spleen and caused dose-dependent oxidative damage
  • Co-administration of wheat germ oil reduced biochemical and immunotoxic markers
  • Nanoencapsulated wheat germ oil formed spherical particles around 174 nm with strong antioxidant activity
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