A process-mining study reconstructs temporal comorbidity trajectories to compare sex and APOE genotype differences in Alzheimer risk.
Key Takeaways
- Cumulative Event Method preserves full ordered diagnostic histories and tracks cumulative morbidity
- UK Biobank nested case-control used 1:1 matching for participants aged fifty-five and older
- Sex-specific trajectories and APOE stratification were validated in an independent CureMD cohort