An article about a lab-developed enzyme designed to reverse a common age-related protein modification, explaining the research approach and implications.
Key Takeaways
- Researchers engineered CMLase via directed evolution from over 500 million variants to target CML modifications
- CMLase oxidizes Nε-carboxymethyl-lysine and restores the native lysine residue on affected proteins
- Enzyme reversed CML modifications in vitro and in human tissue samples from elderly donors