Read about a study testing a plant alkaloid's effects on nematode resistance to Candida infection and associated molecular pathway changes.
Key Takeaways
- 10 μM chelerythrine extended lifespan of Caenorhabditis elegans infected with Candida albicans
- Lifespan benefit was abolished in daf-16 and nhr-49 mutant worms
- Chelerythrine upregulated FoxO and fatty acid metabolism genes including fat-5, fat-6, fat-7