Epigenetic clock research that tracks how repeated DNA methylation measures change over years and what such trajectories imply for long-term survival. A concise, curiosity-sparking preview of a longitudinal study exploring dynamic biomarker trends and their potential value for aging research.
Key Takeaways
- Faster longitudinal increases in several epigenetic clocks correlated with higher mortality risk in the InCHIANTI cohort
- Associations remained after adjusting for baseline epigenetic age and common confounders
- Study followed 699 adults longitudinally for up to 24 years and analyzed multiple clock generations