A review of how chronic cGAS-STING activation contributes to neuroinflammation in aging brains and challenges for selective therapeutic targeting.
Key Takeaways
- CGAS senses cytosolic double-stranded DNA and activates STING-driven interferon responses
- Aged brain cells show excessive cGAS-STING activation partly from mitochondrial DNA leakage
- Preclinical inhibition of cGAS or STING reduced IFN-I, neuronal loss, and improved outcomes