Analysis of transcriptomic datasets with experimental follow-up highlights immune-linked biomarker candidates implicated in periodontitis and diagnostic potential.
Key Takeaways
- CD48 and CXCR4 were consistently upregulated in periodontitis across independent datasets
- CXCR4 showed AUCs of 0.911 and 0.891 indicating strong diagnostic performance
- Validation confirmed increased CXCR4 and CD48 mRNA and protein in human and rat tissues