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Case report:Transformation to SCLC From EGFR-Mutated Squamous Cell Lung Carcinoma During Osimertinib Treatment

Source: Frontiers - Health • Published: 14 Jul 2026, 00:00

Case report:Transformation to SCLC From EGFR-Mutated Squamous Cell Lung Carcinoma During Osimertinib Treatment

Reports a case where an EGFR-mutated squamous cell lung carcinoma transformed into small cell lung carcinoma during osimertinib therapy, with retained EGFR mutation.

Key Takeaways
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  • We report the case of a 42-year-old male initially diagnosed with stage IIIA EGFR-mutated SCC
  • Upon clinical progression during osimertinib therapy, a repeat biopsy was performed
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