A preclinical rat study examining whether a natural isoflavone reduces chemotherapy-induced cardiac injury and which signaling pathways are affected.
Key Takeaways
- Study used randomized blinded groups with oral Biochanin A at 25 and 50 mg/kg
- Biochanin A reduced histological and biochemical markers of doxorubicin cardiotoxicity in rats
- Protective effects coincided with increased PI3K/Akt/mTOR signaling and reduced p38 MAPK activation