Examine research exploring how maternal age alters embryonic autophagy and potential implications for early development and fertility practice.
Key Takeaways
- Embryos from aged females exhibit a pronounced decline in autophagy activity
- Autophagy failure prevents LC3B-mediated ACOX1 degradation, elevating ACOX1 and beta-oxidation
- Rapamycin supplementation improved early embryonic development and the mechanism is conserved in humans