How aging may reshape bile acid metabolism and the gut microbiome — a readable research summary that previews links to intestinal barrier decline and inflammation.
Key Takeaways
- Aging associates with a reduced fecal primary-to-secondary bile acid ratio
- Older adults show gut microbiome shifts toward bacteria with 7α-dehydroxylation activity
- Altered bile acid pools correlate with intestinal barrier dysfunction and elevated systemic inflammation markers