Read about applying AI to prioritize CRISPR screen hits in keratinocytes to find potential therapeutic targets for psoriasis.
Key Takeaways
- Genome-wide CRISPR knockout screen identified regulators of keratinocyte surface IL17RA
- AI model VirtualCRISPR prioritized screening hits for experimental validation
- Topical ALOX5 inhibitor zileuton and OXTR antagonist cligosiban suppressed psoriasiform dermatitis in mice