A perspective piece exploring how nuclear transport and karyopherins might shape cellular aging, and why this idea reshapes thinking about proteome organization.
Key Takeaways
- Karyopherins are presented as active regulators of proteostasis and phase behavior rather than passive transporters
- Age-dependent failure of karyopherin-mediated nucleocytoplasmic transport is proposed as a unifying aging mechanism
- Targeting karyopherin function is suggested as a potential intervention strategy to restore protein compartmentalization