Survey of current approaches to rejuvenating aged regenerative cells, focusing on practical preconditioning, senolytics, and engineered niche strategies for clinics.
Key Takeaways
- Preconditioning and senolytics are primary rejuvenation methods used to restore stem cell function
- Quercetin removed senescent MSCs and improved proliferation and osteogenic potential
- MSC-loaded hydrogels with exosomes rejuvenated skin and enhanced collagen formation in older mice