A literature review surveys cellular and systemic strategies to restore aged hematopoietic stem cell function and delay immune system decline.
Key Takeaways
- CASIN, a Cdc42 inhibitor, restored HSC polarity and modestly extended lifespan in aged mice
- Nicotinamide riboside and mTOR inhibition improved mitochondrial function and regenerative capacity of aged HSCs in mice
- Senolytic ABT263 cleared senescent HSCs and partially restored hematopoietic regeneration after irradiation