Describes a programmable tetrahedral DNA nanostructure platform and stepwise protocol for precisely placing capture ligands to enrich cells and proteins for regenerative and analytical uses.
Key Takeaways
- Conventional multivalent platforms suffer from uncontrolled ligand distribution and poor spatial alignment
- This versatile platform enables the rational design of high-efficiency capture agents for diverse biological targets
- 2: Overview of the procedure from topology-guided design to in vivo validation of TDN capture platforms