Age-related decline in lung repair gets a research-focused examination, highlighting experimental approaches and potential therapeutic leads.
Key Takeaways
- Aged mice showed impaired pulmonary fibrosis resolution and decreased fPRDM16 expression
- Aged fibroblasts had reduced collagen phagocytosis, higher lysosomal pH, and increased mitoROS
- FPRDM16 overexpression restored phagocytosis, normalized lysosomal acidification, and lowered mitoROS