A combinatorial biomaterial and vesicle therapy is evaluated for modulating fibroblast-driven hypertrophic scarring and local delivery.
Key Takeaways
- Graphene–collagen cryogel reduced COL1A1, α-SMA, and Vimentin expression in HS fibroblasts
- Adipose stem cell apoptotic vesicles decreased collagen and α-SMA expression in vitro
- Combined cryogel plus vesicle treatment lowered scar elevation index and increased M2 macrophages