Summarized by Masters of Longevity from Aging Cell.
Epigenetic clocks and their limits: a concise guide to when clock readouts may mislead and how readers can judge study reliability.
Key Takeaways
- Epigenetic clocks can produce false positive signals when interventions alter cell composition rather than biological aging.
- Validation against multiple independent biomarkers or functional endpoints is necessary to confirm clock-based effects.
- Study design must control for confounders like tissue heterogeneity, sample handling, and statistical overfitting.
