Summarized by Masters of Longevity from Nature - Biotechnology.
Yak collagen byproducts are profiled using computational screening and lab tests to highlight candidate anti‑aging peptides and their experimental follow-up.
Key Takeaways
- An ESM-2 based model AgeAttnMLP screened yak collagen sequences and achieved AUCs of 0.891 and 0.879 in validations.
- Three peptides were prioritized and GEPGAPGE inhibited MMP-1 with an IC50 of 126 μg/mL.
- All three peptides increased Caenorhabditis elegans lifespan, with GPSGEPGTA giving the largest effect at 7.5 mg/mL.
