Summarized by Masters of Longevity from Frontiers - Health.
A review summarizes recent advances using extracellular vesicles as liquid biopsy biomarkers for diagnosing and staging central nervous system disorders, especially neurodegenerative diseases.
Key Takeaways
- EVs carry CNS-derived proteins like phosphorylated tau and alpha-synuclein that show disease-specific differential expression patterns.
- EV-associated noncoding RNAs such as miR-422a and miR-409-3p have been reported as potential diagnostic markers for neurodegenerative conditions.
- Clinical translation remains limited because head-to-head validation versus conventional CSF biomarkers in the same cohorts is still lacking.
