Summarized by Masters of Longevity from Nature Aging.
Human endothelial cell aging is explored through an integrated single-cell atlas, inviting readers to learn how cellular programs shift across tissues and adulthood.
Key Takeaways
- A harmonized single-cell atlas maps transcriptional aging patterns across human endothelial cells.
- Aging endothelial cells exhibit reduced angiogenic genes and altered extracellular matrix programs.
- A p21-linked transcriptional program correlates with endothelial cell senescence in models.
