Summarized by Masters of Longevity from Aging Cell.
Human-to-pig gut microbiota transfer study—invites readers to see how elderly donor communities reshape host intestinal biology and systemic metabolites.
Key Takeaways
- Human elderly donor microbiota engrafted in pigs and altered intestinal barrier markers compared with recipients of younger microbiota.
- Plasma metabolome shifted after transplantation, showing distinct metabolite profiles linked to the elderly microbiota.
- Gut mucosal transcriptomes were reprogrammed, with age-associated gene expression changes observed in recipient pig intestines.
