Summarized by Masters of Longevity from Nature Aging.
Reports a transcriptomic reprogramming screen that nominates the splicing factor SRSF1 as a conserved regulator capable of restoring youthful transcriptomes and improving organismal aging measures.
Key Takeaways
- A cDNA overexpression screen in human fibroblasts identified SRSF1 as shifting aged transcriptomes toward younger states.
- Induced SRSF1 reduced senescence, proteostatic stress, and inflammatory signaling in vitro without disrupting cell identity.
- Inducible SRSF1 expression in aged mice slowed frailty progression by 44% and extended median lifespan by 14%.
