Summarized by Masters of Longevity from Fight Aging!.
Epigenetic-aging research that evaluates when molecular clocks can reliably indicate intervention effects, offering practical criteria to boost confidence before trusting results.
Key Takeaways
- Extending prior single-clock intervention studies to multiple clocks found no additional clocks reached statistical significance.
- Three proposed criteria increase confidence: principal component based clocks respond, mortality-trained or pace-of-aging clocks respond, and multiple clocks shift the same direction.
- Simulation and longitudinal control data show more reliable clocks are more sensitive and correlated when true biological effects occur.
