Summarized by Masters of Longevity from Aging Cell.
Rapamycin’s effects on immune and vascular aging are examined in this article, offering a concise preview of experimental research into therapeutic immunomodulation.
Key Takeaways
- Systemic rapamycin treatment reduced inflammatory cell content within atherosclerotic plaques in aged mice.
- Rapamycin altered lymphoid immune responses, shifting immune cell phenotypes consistent with reduced proinflammatory activity.
- Immunomodulation via mTOR inhibition with rapamycin presents a potential strategy to attenuate vascular aging and plaque inflammation.
