Summarized by Masters of Longevity from Fight Aging!.
Reports that the neuropeptide catestatin lowers pathological tau, reduces neuroinflammation, and improves cognition in mouse tauopathy models.
Key Takeaways
- Catestatin supplementation decreased phosphorylated and aggregated tau species in PS19 tauopathy mice.
- Catestatin treatment reduced gliosis and improved cognitive performance in treated mice.
- Catestatin lowered epinephrine and suppressed PKA hyperactivation, linking adrenergic signaling to tau pathology modulation.
