Summarized by Masters of Longevity from Fight Aging!.
New research links gut-derived indole from certain Escherichia coli strains to worsening inflammatory immune responses after ischemic stroke, and identifies an immune receptor pathway as an intervention point.
Key Takeaways
- Enrichment of indole-producing Escherichia coli correlated with worse stroke outcomes in mice and human patients.
- Microbial indole activated an AHR-dependent response in dendritic cells that exacerbated post-stroke neuroinflammation.
- DC-specific AHR deletion or pharmacological AHR inhibition reduced neuroinflammation and improved stroke outcomes via increased Tregs.
