Summarized by Masters of Longevity from Fight Aging!.
Study finds the APOE4 Alzheimer’s risk allele disrupts Wnt signaling in oligodendrocytes, causing lipid droplet buildup and reduced myelination in models.
Key Takeaways
- This myelin sheathing is required for effective communication between neurons.
- Further analysis revealed how Wnt signaling became depressed in cultured APOE4 oligodendrocytes.
- The team then tested interventions that manipulate GSK3b activity.
