Summarized by Masters of Longevity from Nature - Biotechnology.
A multicomponent rigid-flexible bioscaffold combining aligned PCL channels, NT3-releasing collagen particles, and BMSC-laden self-healing hydrogel restored tissue and function after complete spinal cord injury in rats.
Key Takeaways
- The composite Poly_NT3_gel scaffold reduced lesion volume and fibrosis in a rat complete spinal cord injury model.
- Scaffold-treated rats showed improved neural bridging, locomotor function, and urinary recovery compared with controls.
- Single-nucleus RNA sequencing indicated the scaffold suppressed post-injury fibroblast proliferation and modulated immune transcriptional states.
