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Splicing Factor SRSF1 Overexpression Produces a More Youthful Transcriptome and Slows Aging in Mice

Source: Fight Aging! • Published: 28 Oct 2026, 10:22

Summarized by Masters of Longevity from Fight Aging!.

SRSF1 overexpression made aged fibroblasts more youthful and extended mouse lifespan.

Splicing Factor SRSF1 Overexpression Produces a More Youthful Transcriptome and Slows Aging in Mice
Key Takeaways
  • A transcriptomic screen identified SRSF1 as a rejuvenation candidate.
  • SRSF1 overexpression reduced senescence, proteostatic stress, and inflammaging.
  • Aged mice given SRSF1 had liver accumulation and 14% longer lifespan.
Read the full article at Fight Aging! ↗

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