Summarized by Masters of Longevity from Longevity Technology.
A Seoul biotech reports an engineering update that raises circular RNA self-circularization efficiency up to sevenfold, potentially easing manufacturing limits for larger RNA constructs.
Key Takeaways
- Researchers modified an STS platform P1 construct with a short polyA10 and antisense sequence to improve circularization efficiency.
- The redesign increased self-circularization efficiency by roughly sevenfold compared with the original STS design.
- Rznomics positions the improved circRNA platform for broader therapeutic use and mentions potential applications including CAR-T therapies.
